British researchers led by David Nutt, a professor of neuropsychopharmacology at Imperial, have been exploring the potential of psilocybin to ease severe forms of depression in people who don’t respond to other treatments.

The World Health Organization estimates that some 350 million people worldwide are affected by depression, a common mental disorder characterised by sadness, loss of interest or pleasure, tiredness, feelings of guilt or low self-worth, disturbed sleep and appetite, and poor concentration.



Many patients respond to treatment with antidepressants and cognitive behavioural therapy, but around 20 percent don’t get better and are classed as having treatment-resistant depression.

Psilocybin acts on the serotonin system, suggesting it could be developed for treating depression. But hallucinogenic drugs can also cause unpleasant reactions, including anxiety and paranoia, so Nutt’s team wanted to find out if psilocybin can be given safely.

The trial involved six men and six women, aged between 30 and 64, all diagnosed with treatment-resistant depression. They all went through a full screening process before being allowed to participate and they were fully supported before, during and after they received psilocybin. The patients were given psilocybin capsules during two dosing sessions, seven days apart.

Blood pressure, heart rate and the self-reported intensity of the effects of psilocybin were monitored during each session, and the patients were seen by a psychiatrist the next day and one, two, three and five weeks after the second dose.

Carhart-Harris said no serious side effects were reported during the study, although all volunteers said they were slightly anxious before and during initial drug administration.

“Psychedelic drugs have potent psychological effects and are only given in our research when appropriate safeguards are in place,” he said. “I wouldn’t want members of the public thinking they can treat their own depressions by picking their own magic mushrooms. That kind of approach could be risky.”

Nutt said the results showed that psilocybin “is safe and fast acting, so if administered carefully, it may have value for these patients.”